သဒ္ဒါ JLPT အဆင့် N3 – သင်ခန်းစာ 4

ところで is a conjunction particle that is made up of the noun, ところ 'place', and the case marking particle で. It is used in a similar way to 'by the way', or 'incidentally' in English, but will only be used for introducing new topics, not continuing within the same topic.
ところで will primarily appear at the beginning of a sentence, before making a statement or asking a question about something unrelated.

• ところで、昨日(きのう)の話(はなし)はどうなった？
  သင့္ညီညာေပါ့, what happened to the plan you told me about yesterday?
• ところで、お宅(たく)の旦那(だんな)さんは元気(げんき)にしていますか。
  သင့္ညီညာေပါ့, is your husband doing well?

The literal translation of ところで is closer to 'and with that', and implies that something (within the previous topic) suddenly reminded the speaker of another thing (that happens to be a new topic).